Binding Sites

AHoJ-DB groups the ligand-binding sites of each protein across all of its PDB entries into unified binding sites (UBS): sites whose binding residues overlap by at least a chosen Jaccard threshold are merged into one. For every unified site you get its member entries and core residues, the AlphaFold model's apo / holo classification with its confidence, how well the observed structures support it (density) and how distinguishable the apo and holo states are (separation), plus a binding-position map and a dendrogram of the whole protein.

Examples: P69905 Hemoglobin subunit alpha, P00918 Carbonic anhydrase 2, P04637 Cellular tumor antigen p53, P46883 Primary amine oxidase

Looking for a protein without knowing its accession? Every AHoJ-DB entry's UniProt view tab opens its protein's unified sites, and Seq Search finds proteins by sequence similarity.